Dr.James is the consultant General Physician In Kochi and diabetologist in Mar Augustine Jubilee Memorial (MAJ) Hospital, Edappally, Cochin. Causes of type 1 diabetes The exact cause of type 1 diabetes is unknown. What is known is that your immune system — which normally fights harmful bacteria or viruses — attacks and destroys your insulin-producing cells in the pancreas. This leaves you with little or no insulin. Instead of being transported into your cells, sugar builds up in your bloodstream. Type 1 is thought to be caused by a combination of genetic susceptibility and environmental factors, though exactly what those factors are is still unclear. Weight is not believed to be a factor in type 1 diabetes.